The three-vehicle crash happened near North Pottstown Pike and Gordon Drive around 11 p.m., said Elverson-Honey Brook Area EMS.
Photos from the scene showed severe damage to two sedans and a tractor-trailer separated from its back set of wheels.
First responders arrived to find one victim trapped but were able to free them after about eight minutes, authorities said.
Uwchlan EMS, Elverson-Honey Brook EMS, Goshen EMS, Good Fellowship EMS, Malvern EMS, East Whiteland EMS, and Lionville Fire Company also responded.
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